| abstract |
The present invention relates to new uses of Eleutheroside E, in particular to the application of Eleutheroside E in the preparation of medicines for preventing and/or treating knee osteoarthritis (KOA) and a pharmaceutical composition for treating knee osteoarthritis (KOA). The pharmaceutical composition for treating knee osteoarthritis can be prepared into injections, tablets, capsules, granules, drops, granules or ointments by adding Eleutheroside E with a purity of more than 98% to common pharmaceutical auxiliary components. Pharmacological experiments show that Eleutheroside E can significantly improve the infiltration of inflammatory cells, fibrous tissue proliferation and cartilage surface destruction in osteoarthritis, and reduce the levels of MMP-3, MMP-9 and PGE 2 in serum. Eleutheroside E has strong anti-inflammatory properties. The role of knee osteoarthritis (KOA). Therefore, Eleutheroside E can be used in the preparation of a medicament for the prevention and/or treatment of KOA. The present invention provides a new drug source for the treatment of KOA. |