http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112457299-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a7e2b9a11a3f71d165e7dd72230437a5 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-04 |
| filingDate | 2020-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f679d9d53bce42e5266e59630272e7ae http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fd691f960df0650c747cf825a432bcba http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6702146662b8cf9a8dce3454d84de535 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_49f6bf9dc61b703be24e69484c8f02c1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a31edefd23bc5852359660aa29a719de |
| publicationDate | 2021-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112457299-A |
| titleOfInvention | Purification methods for EGFR inhibitors |
| abstract | The present invention relates to purification methods of EGFR inhibitors. Further, relate to the purification method of the compound of formula (I), specifically, mix the compound of formula (I) with solvent A, directly crystallize after heating and dissolving, or add solvent B and then crystallize again, wherein, solvent A is 2- Methyltetrahydrofuran, solvent B is selected from one or more of n-heptane, n-hexane and pentane. The product obtained by the method of the invention has good purity, high yield, simple process operation, and can significantly reduce the residue of dimer impurities represented by formula (II), thereby ensuring drug safety. |
| priorityDate | 2020-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 39.