| abstract |
The invention relates to an optic nerve repair composition and a preparation method and application thereof, comprising the following steps: mixing Rho kinase inhibitor, activated platelet-rich plasma and stem cells, and then culturing at 2°C to 37°C for 8 to 72 hours to obtain The optic nerve repair composition. The invention specifically targets the pathogenic factors of abnormal blood vessel function, elevated intraocular pressure and optic nerve cell damage in patients with ophthalmic diseases, and for the first time combines stem cells, PRP and Rho kinase inhibitors to establish a new three-dimensional cascade interaction mechanism. The close synergistic effect of PRP, stem cells and Rho kinase inhibitors suggests that PRP and Rho kinase inhibitors may promote the function of EPC, jointly secrete cytokines, promote the repair of vascular endothelium and optic nerve cells, rebuild vascular function, and reduce intraocular pressure. Alleviate retinal damage and reduce retinal cell apoptosis. |