| abstract |
The invention discloses an anti-abuse oxycodone sustained-release tablet and a preparation method thereof. An anti-abuse oxycodone sustained-release tablet, comprising at least: 1) 2-9 parts by weight of oxycodone-loaded cellulose with nano-network structure; 2) 5-13 polymers with swelling properties in alcohol and water parts by weight; wherein, the oxycodone is dispersed on the surface of the cellulose with nano-network structure. The oxycodone sustained-release tablet of the present invention has obvious sustained-release effect, no obvious burst release, and excellent anti-abuse properties. |