http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112442101-A

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filingDate 2019-10-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8e9de91f7701f4a700cd2dceac0256a5
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publicationDate 2021-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-112442101-A
titleOfInvention Oligonucleotide synthesis method and synthesis device
abstract The present application provides a method and device for synthesizing oligonucleotides. The method includes: adding a first compound to a hydrophilic area of a first microarray bottom plate, reacting a hydroxyl group in the hydrophilic area with a carboxyl group of the first compound to obtain a second compound including a carboxyl group, and passing the first compound through the hydrophilic area The second compound reacts with thymidine with a hydroxyl group to obtain a synthetic oligonucleotide in the hydrophilic region. The above technical solution can only modify the bottom plate once to synthesize oligonucleotides, which can improve the synthesis efficiency of oligonucleotides, reduce the production cost of oligonucleotides, and make the entire operation process take less time.
priorityDate 2019-09-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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