http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112442094-B

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filingDate 2020-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2023-01-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2023-01-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-112442094-B
titleOfInvention Separation and Purification of Tylosin Using Liquid Thermoresponsive Polymer EO20PO80
abstract The invention relates to the separation and purification of tylosin by using a heat-responsive polymer ethylene oxide-propylene oxide random copolymer aqueous solution to form two aqueous phases through temperature induction. In the present invention, the EO 20 PO 80 and the tylosin fermentation broth are uniformly mixed according to the volume ratio of 1:5, the pH is adjusted to 9.0, and a two-water phase system is formed by temperature induction, so that the tylosin in the fermentation broth is transferred and Enriched in the lower phase EO 20 PO 80 ; by removing the upper phase and adding an equal volume of water to it to adjust the pH to 4.5, the tylosin was transferred from the lower phase EO 20 PO 80 by temperature induction and It is enriched in the upper phase aqueous solution, and the separation and purification of tylosin are realized by forward extraction and reverse extraction. Through temperature adjustment, the recovery rate of the heat-responsive polymer reaches 99.53%.
priorityDate 2020-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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Total number of triples: 24.