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filingDate 2019-08-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e0007d49f51bd95288bee612fde91ac
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publicationDate 2021-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-112438951-A
titleOfInvention A kind of method for preparing isoniazid preparation and preparation thereof
abstract The invention belongs to the technical field of pharmacy, and particularly relates to a preparation method for reducing the content of free hydrazine in an isoniazid preparation, a prepared isoniazid tablet and a preparation method for reducing impurities in an isoniazid preparation. The preparation method adopts the direct compression method to compress the composition of the isoniazid preparation to obtain the preparation with low free hydrazine content, the composition is composed of isoniazid, filler, crospovidone, glidant , hydrogenated vegetable oil composition. Compared with the wet granulation method used in other inventions, the direct compression method has higher chemical stability and produces less free hydrazine and related impurities; the preparation method avoids the influence of water on active substances , and no high temperature state is generated, thereby improving the safety of the product.
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