| abstract |
The invention belongs to the technical field of organic chemistry, and particularly relates to a preparation method of an axial chiral 4-substituted cyclohexylidene aryl acetate chiral compound. The invention takes cis-4-substituted cyclohexyl-alpha-hydroxy diazo ester compounds as raw materials, and reacts with aryl iodides to prepare the chiral compounds of axial chiral 4-substituted cyclohexylidene aryl acetate under the condition that palladium sources and chiral ligands are coordinated to form chiral palladium species as catalysts. The invention has the advantages of simple and easily obtained reaction raw materials, mild reaction conditions, high yield, good regioselectivity and stereoselectivity of the reaction, wide application range of the substrate and convenient separation and purification. The axial chiral compound prepared by the invention has good functional group compatibility and can be flexibly converted, and the framework is an important chiral block for preparing a chiral drug intermediate and a chiral ligand, and has important application value and wide application prospect. |