http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112410430-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-158 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-178 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-106 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K33-243 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K33-243 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6886 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06 |
| filingDate | 2020-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112410430-B |
| titleOfInvention | A marker related to the resistance of tumor cells to cisplatin and its application |
| abstract | The invention discloses a marker related to the resistance of tumor cells to cisplatin. The marker is miR-122b-3p, and its nucleotide sequence is shown in SEQ ID NO.1. The present invention finds that miR-122b-3p can be used as a marker of tumor cell drug resistance by establishing SK-OV-3/DDP drug-resistant cell lines; miR-122b-3p is resistant to DDP in SK-OV-3/DDP cells It can reverse the resistance of SK-OV-3/DDP cells to DDP by down-regulating miR-122b-3p; and can inhibit the proliferation rate of ovarian cancer SK-OV-3/DDP cells, and also inhibit its Cloning ability. This provides a scientific basis for finding new molecular therapeutic targets, guiding clinical medication, and more effectively combating cisplatin resistance. |
| priorityDate | 2020-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 73.