| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_393519b388d3b4e1138df936df8e85eb |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K2211-1088 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-6486
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D407-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K11-06 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C09K11-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D407-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N21-64 |
| filingDate |
2020-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7def6f7e967f40ca773bdb5b21193924
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ded9141c4552fec2ed65e0af882ace6c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_98f085e78332e4b62b170192354bc828
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2fa3bd847475d9d21a105f2de9916ff2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0329f5d6b54f8bac44959a7546b05df7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_466666bd90f575b8ade80efe2ee11510 |
| publicationDate |
2021-02-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-112391160-A |
| titleOfInvention |
A near-infrared fluorescent probe for intracellular N2H4 detection and preparation method thereof |
| abstract |
The invention discloses a fluorescent probe molecular structure based on an acetyl group with strong electron withdrawing properties as a recognition group, xanthene as a molecular basic skeleton, and a tricyanofuran group modified with strong electron withdrawing properties. In the presence of N 2 H 4 , the carbonyl group of the needle molecule is attacked by hydrazine nucleophile, and the hydroxyl group with strong electron-donating properties is released, and then a conjugated large π bond with a strong push-pull electron structure is formed. The fluorescence emission of the probe molecule is red-shifted and The fluorescence was significantly enhanced with a large Stokes shift (186 nm), and the color of the solution changed from purple to pale yellow, enabling visual detection of hydrazine as well as intracellular hydrazine detection. |
| priorityDate |
2020-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |