http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112390962-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-87 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G83-008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08B37-0015 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08B37-0072 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G83-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08B37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08B37-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-87 |
| filingDate | 2020-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112390962-B |
| titleOfInvention | Enzyme-responsive polysaccharide supramolecular assembly for plasmid DNA controlled release and preparation method thereof |
| abstract | An enzyme response polysaccharide supermolecule assembly for plasmid DNA controlled release and a preparation method thereof. The assembly construction unit is adamantane modified hyaluronic acid and tetraethylenepentamine modified cyclodextrin, a polysaccharide supramolecular assembly with hyaluronidase responsiveness is constructed through the host-guest action between the cyclodextrin and adamantane, and the particle size of the assembly is about 100 nm. The invention has the advantages that: 1) the water solubility and the biocompatibility of the assembly can be effectively improved by introducing hyaluronic acid and beta-cyclodextrin; 2) the assembly can gather polyamine chains together to enhance the action of the assembly on plasmid DNA, so that the wrapping capacity of the assembly on the plasmid DNA is improved; 3) the pair of response systems of hyaluronic acid-hyaluronidase is successfully applied to the construction of an enzymatic response nano assembly, and controllable wrapping and release of plasmid DNA can be realized; 4) the assembly body has simple construction method, easy implementation and low cost of raw materials, and has good application prospect in the field of gene delivery. |
| priorityDate | 2020-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 48.