| abstract |
The present disclosure relates to pyridinenicotinamide derivatives, their preparation methods and their medical applications. Specifically, the present disclosure relates to a pyridine nicotinamide derivative represented by general formula (I), a preparation method thereof, a pharmaceutical composition containing the derivative, and its use as a therapeutic agent, especially as a Na V 1.8 inhibitor. Use and use thereof in the manufacture of a medicament for the treatment and/or alleviation of pain and pain-related diseases. Wherein each substituent of the general formula (I) is as defined in the specification. |