http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112375137-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-765 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-765 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-14 |
| filingDate | 2020-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112375137-B |
| titleOfInvention | A kind of preparation method of human albumin that effectively reduces PKA content |
| abstract | The present invention is a preparation method of human albumin which can effectively reduce the content of PKA. In the FIV separation process, phosphate is used to control the ionic strength, the solubility of albumin is improved and the solubility of PKA is reduced at the same time, so as to precipitate and remove more PKA. Human albumin with low PKA content is obtained; in the downstream of product preparation, the combination of A50 gel adsorption and activated carbon filter plate adsorption is used to remove impurities. A50 gel mainly adsorbs serine proteases such as PKA, haptoglobin and alpha acid glycoprotein. , Activated carbon filter plate mainly adsorbs heme, endotoxin and serine protease, etc. Therefore, in the downstream of product preparation, the combination of A50 gel adsorption and activated carbon filter plate adsorption can effectively reduce PKA content, improve product appearance and reduce endotoxin content, reduce polymer content, improve albumin purity and product safety; pretreatment of A50 gel makes the adsorption effect of A50 gel better. |
| priorityDate | 2020-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 246.