http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112374976-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2704a6820a4e24cc3c7a8b88ee0c6b9c |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-81 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-40 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C47-575 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C47-565 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-255 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-81 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-74 |
| filingDate | 2020-11-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a3780add05a08f18faf462ff8ffd6de9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cd3ff7588ccda93e2a906603d84aefd1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8a6cf7002f69c02d23f6bdb1eaedc90f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_22fd3e32b22ad1ef6161e0b71788f4a9 |
| publicationDate | 2021-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112374976-A |
| titleOfInvention | A new method for synthesizing curcumin analogs |
| abstract | The invention discloses a preparation method of a curcumin analog, and the structural formula of the curcumin analog is as follows: The synthesis method includes the following steps: reacting o-hydroxy-trans-cinnamic acid and ozone to obtain salicylaldehyde; using methyl iodide as a methylating reagent, and performing methylation reaction to obtain a product 2-methoxybenzaldehyde; 2-methoxybenzaldehyde React with acetone, use potassium methoxide as base, and obtain the curcumin analog after recrystallization. Compared with the prior art, the method does not use any precious metal catalyst or halogenated solvent, has less pollution, and is easy to operate in the reaction process. The obtained final product has a purity of more than 99%, simplifies purification steps, and avoids separation and purification by silica gel column chromatography. Therefore, the method is easy to operate, greatly reduces production costs, and does not generate a large amount of solid waste and waste liquid. At the same time, the present invention uses the method of ozonolysis, avoids the use of various oxidizing reagents, and reduces the use of organic reagents and solvents. |
| priorityDate | 2020-11-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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