| abstract |
Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds to treat cancer. The compound of structural formula (II), or a pharmaceutically acceptable salt thereof: wherein: R 1 is pyridin-3-yl, pyridin-4-yl, pyrazol-4-yl, cyclohexyl or 8-azabicyclo[3.2 .1] oct-2-en-3-yl, wherein R 1 is optionally substituted by up to four independently selected substituents; R 2 is cyclohexyl, substituted by hydroxy, and optionally by one or two independently substituted with another substituent selected from C 1 -C 4 alkyl and fluorine, or R 2 is 4,5,6,7-tetrahydro-1H-indazolyl, which is optionally substituted by 1-3 independently and R 3 is -C 3 -C 8 alkyl, -(C 2 -C 6 alkylene)-O- (C 1 -C 6 alkyl), C 3 -C 6 cycloalkyl or -(C 2 -C 6 alkylene)-C 3 -C 6 cycloalkyl, wherein R 3 is optionally 1-5 independently selected from deuterium , halogen and ‑OH substituents. |