| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5d403ad2b9c020e1848f6ba57e189f86 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-76
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2300-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-24 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-165
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-145
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4184
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4375
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-437
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-436
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4523
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-39558
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2863
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-517
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-505
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5415 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-277
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 |
| filingDate |
2016-02-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c7add7647b5f31ee71f5f68d4ed4cdaa
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_73150f89ff59d2f298b41dba93a451be
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_396231da04dd9dfcaec9446d7217ccd5 |
| publicationDate |
2021-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-112353938-A |
| titleOfInvention |
Combination of IRS/STAT3 dual modulator and anticancer agent for the treatment of cancer |
| abstract |
The present invention relates to a combination of a dual modulator of IRS/STAT3 and an anticancer agent for the treatment of cancer. Specifically, the present invention provides a combination of a compound of formula (III) or (IV) with the following agents: (i) a mitogen-activated protein kinase (MEK) inhibitor and/or a mutated B-Raf inhibitor; ( ii) anticancer drugs; (iii) immunotherapeutic agents; (iv) epidermal growth factor inhibitor (EGFR) inhibitors and/or EGFR antibodies; (v) chemotherapeutic agents; and (vi) mTOR inhibitors, or their certain combinations. The combination provides an at least additive, preferably synergistic, therapeutic effect. The present invention also relates to the treatment of cancer using a combination therapy comprising a dual modulator of IRS and Stat3 in combination with an immunotherapeutic agent. The combination can be used to sensitize tumors to immunotherapy. |
| priorityDate |
2015-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |