http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112353752-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-517 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0042 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-54 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B82Y5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-517 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-54 |
| filingDate | 2020-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112353752-B |
| titleOfInvention | A light-driven drug-loading system for optic nerve restoration and its preparation method and application |
| abstract | The invention discloses a light-driven drug-loading system for optic nerve restoration and a preparation method thereof. The preparation method of the drug-loading system of the invention mainly includes: 1) preparing mesoporous silica nanoparticles (MSN); 2) preparing MSN ‑SH nanoparticles; 3) preparation of gold nanoparticles; 4) preparation of MSN‑S‑Au nanoparticles; 5) preparation of Janus nanoparticles; 6) preparation of Janus nanoparticles drug delivery system. The drug-carrying system provided by the invention reduces the release rate of the drug and improves the bioavailability. The N-trimethoxysilylpropyl-N,N,N-trimethylammonium chloride provided by the present invention provides a positive charge for the surface of the drug-loading system, which can effectively enhance the adhesion of the drug-loading system on the inner limiting membrane of the retina. Attached performance. The drug-carrying system provided by the invention has an asymmetric structure, and generates a local temperature gradient in the near-infrared region, driving Janus nanoparticles to move toward the retinal inner limiting membrane focus area. |
| priorityDate | 2020-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 76.