| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2e3830f35387a1c32061dea3ee310851 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2750-14143
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2750-14121
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2750-14122 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N7-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-861
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-01 |
| filingDate |
2019-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5a60de7ad1651f87ed426bc42e3c06eb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_09fc4ac0c4e08cf51f4d4e410ec498d2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e028aa69209ed82f4e2efe7dfa01791e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fab790ac603cb62013ad51e81938d86a |
| publicationDate |
2021-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-112352050-A |
| titleOfInvention |
Novel adeno-associated virus (AAV) vectors, AAV vectors with reduced capsid deamidation, and uses thereof |
| abstract |
A recombinant adeno-associated virus (rAAV) vector comprising an AAV capsid having a heterogeneous population of vpl proteins, a heterogeneous population of vp2 proteins, and a heterogeneous population of vp3 proteins. The capsid contains modified amino acids compared to the encoded VP1 amino acid sequence, the capsid contains a highly deamidated asparagine residue at an asparagine-glycine pair, and further comprises a plurality of Other less deamidated asparagine and optionally glutamine residues. Methods are provided for reducing deamidation in the AAV capsid of rAAV. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023125481-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115011601-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115011601-B |
| priorityDate |
2018-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |