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filingDate 2020-10-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2022-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2022-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-112342115-B
titleOfInvention Microfluidic chip for capturing and/or counting cells and preparation method and application thereof
abstract The invention is applicable to the technical field of biological detection,provided are a microfluidic chip for capturing and/or counting cells, a method for preparing the same, and applications of the same, the microfluidic chip including: a first base layer; an anti-opal photonic crystal structure modified by antibody, arranged on the first substrate, comprising an antibody modification layer and Yb doped with the same 3+ And Er 3+ The yttrium vanadate inverse opal structure layer; the second base layer is arranged on one side, close to the anti-opal photonic crystal structure modified by the antibody, of the first base layer; and the micro-fluidic cavity is arranged between the first base layer and the second base layer. The invention controls the photonic band gap by regulating and controlling the minimum repeated unit size of the photonic crystal to manufacture double layers of Yb doped with different apertures and different band gaps 3+ And Er 3+ The inverse opal structure of yttrium vanadate can enable up-conversion green light emission to obtain an obvious enhancement effect through the band gap effect of the photonic crystal, and solves the problem of insufficient fluorescence intensity caused by low quantum efficiency in the existing up-conversion luminescence process.
priorityDate 2020-10-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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