http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112341354-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-47 |
| filingDate | 2020-09-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112341354-B |
| titleOfInvention | PMS synthesis method |
| abstract | The invention discloses a PMS synthesis method, and belongs to the technical field of organic synthesis. The method comprises the steps of reacting L-serine methyl ester hydrochloride with palmitoyl chloride to obtain N-palmitoyl-L-serine methyl ester; protecting N-palmitoyl-L-serine methyl ester through benzyl, and hydrolyzing the methyl ester to obtain N-palmitoyl-O-benzyl-L-serine; esterifying N-palmitoyl-O-benzyl-L-serine with tetradecanol to obtain N-palmitoyl-O-benzyl-L-serine tetradecyl ester; finally, debenzylating the N-palmitoyl-O-benzyl-L-serine tetradecyl ester to obtain PMS. According to the invention, cheap L-serine methyl ester hydrochloride is used as a raw material, and the hydroxyl group is protected by benzyl, so that the side reaction of unprotected hydroxyl group in a serine parent body and esterification of tetradecanol is effectively avoided, the reaction conversion rate is improved, the difficulty of separation and purification caused by byproducts is reduced, and the method can be effectively applied to industrial mass production. |
| priorityDate | 2020-09-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 102.