| abstract |
The invention relates to the field of pharmaceutical preparations, in particular to a long-acting pulse preparation and a preparation method thereof. The long-acting pulse preparation includes a pulse-controlled release layer, on which the hypoglycemic drug is supported, the pulse-controlled release layer is a pH-sensitive controlled-release layer, and the initial pH of dissolution of the pulse-controlled release layer is 4 . In the present invention, the hypoglycemic drug is loaded on the pH-sensitive pulse-controlled release layer, and the pH value fluctuation in the stomach after meals is used to control the release of the drug, so that the hypoglycemic drug can be released after the pH value of the patient's stomach rises after each meal. The effect of releasing the drug and not releasing the drug after the pH value drops on an empty stomach can significantly reduce the frequency of taking the drug, and effectively avoid the adverse reactions caused by the inaccurate matching of postprandial blood sugar rise and hypoglycemic drug release timing, such as the occurrence of hypoglycemia symptoms . |