http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112326860-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_979f297f3d2b907d339d8def1eb9d30c |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2030-884 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-88 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-88 |
| filingDate | 2020-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f990f1ea7ac8f48b804ef93ae9447ba7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_304668777bc718e202ac264e42b25dfd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bf0c9abe155f2d7bb93eef00b7da9fe2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ffb91a7dd1c8575b87248214fb782653 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1d7fe78d9b19f77b7885b592a8502ad0 |
| publicationDate | 2021-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112326860-A |
| titleOfInvention | Method for simultaneous detection of 1,4-dichlorobutane and 1-chloro-4-hydroxybutane genotoxic impurities in drug substance or preparation |
| abstract | The invention relates to the technical field of analysis and detection, in particular to a method for simultaneously detecting genotoxic impurities of 1,4-dichlorobutane and 1-chloro-4-hydroxybutane in raw materials or preparations. The method for the simultaneous detection of 1,4-dichlorobutane and 1-chloro-4-hydroxybutane genotoxic impurities in raw materials or preparations is detected by gas chromatography-mass spectrometry, using EI ion source, headspace For phase analysis, methyl tert-butyl ether was used as the internal standard, and the content of impurities in the sample was calculated by the internal standard method. The present invention solves the problem that the current detection limit of genotoxic impurities cannot be reached, and simultaneously fills the problem of simultaneously detecting 1,4-dichlorobutane and 1-chloro-4-hydroxybutane genotoxic impurities in raw materials or preparations. The vacancy of the method, the detection limit reaches ppm, the sensitivity is improved, the repeatability is good, and the response is high. |
| priorityDate | 2020-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.