| abstract |
The invention discloses anti-Tim3 antibody, chimeric antigen receptor and application thereof. The chimeric antigen receptor disclosed in the present invention includes an antigen binding portion of an anti-Tim3 antibody; a hinge region and a transmembrane domain; a costimulatory domain; and a signal transduction domain. The present invention also discloses nucleic acid molecules encoding chimeric antigen receptors, expression vectors, host cells, and pharmaceutical compositions and kits containing the same. The chimeric antigen receptor of the present invention can be used in immunotherapy and has huge market application value. |