| abstract |
The invention discloses a magnolol derivative, a magnolol derivative and its hydrochloride, a preparation method and an application. Magnolol derivatives, honokiol derivatives and their hydrochloride salts have the structures shown in the following formula (I), Formula (I), apply the technical scheme of the present invention, utilize the method of chemical synthesis to modularly prepare honokiol derivatives, and honokiol derivatives and their hydrochloride C14 atom markers and D atom markers, both of which are available Studies on the drug metabolism of honokiol derivatives, and honokiol derivatives and their hydrochlorides. Among them, the use of C14-labeled technical substances can well solve the problem of low drug recovery in traditional drug metabolism experiments, and facilitate the elucidation of the processes related to the absorption, distribution, metabolism and excretion of such drugs in vivo. |