http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112300186-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9d8879615a983dd87fb7eb03b5bd6a72 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D493-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-20 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-04 |
| filingDate | 2019-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1f5d7c57afbf3b01079270d9b5d94a70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bcdbe4706a5b22250462849f9d4109de http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_575d73912e696dcf9ab2de1c46e30072 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0565133772d20aaee469f20367dfa4e3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_67d40d01d9a097953847014deafea243 |
| publicationDate | 2021-02-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112300186-A |
| titleOfInvention | Preparation method of hexahydrofuranofuran alcohol derivative, intermediate thereof and preparation method thereof |
| abstract | The invention relates to the field of pharmaceutical synthesis, in particular to a preparation method of a hexahydrofuranofuran alcohol derivative, an intermediate thereof and a preparation method thereof. The preparation method includes condensation reaction, deprotection and cyclization reaction, Wherein, R 1 and R 2 are hydrogen or hydroxyl protecting groups, R 3 is an alkyl group, an acyl group, an ether group, an ester group or an aryl group, and X is oxygen, sulfur or nitrogen. In the preparation process of the hexahydrofuranofuran alcohol derivative, the compound of formula I is subjected to a condensation reaction, and the product can be prepared with very high optical purity by adopting such a route. The preparation method can be commercialized to prepare the key intermediate (3R, 3aS, 6aR)-hexahydrofuro[2,3-b]-3-alcohol of darunavir, which is a very economical and suitable route for industrial production . |
| priorityDate | 2019-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 117.