| abstract |
The invention relates to a co-amorphous compound of clozapine and quetiapine fumarate and a preparation method thereof. The invention finds that the combination of clozapine and quetiapine fumarate has a synergistic effect and can be used for the treatment of various types of schizophrenia, even including refractory schizophrenia. The present invention provides a co-amorphous compound formed by clozapine and quetiapine fumarate, which has good performance in terms of bioavailability, therapeutic effect, pharmacodynamic stability, process developability and storage property, especially its treatment The effect was significantly better than a simple mixture of clozapine and quetiapine fumarate. |