| abstract |
The invention discloses a 3D printing Ti-PDA-PLGA microsphere bone defect repair stent and a preparation method thereof. Preparing a 3D printing Ti support by a laser sintering technology; then under a certain condition, enabling dopamine to be polymerized on the fiber surface of the 3D printing Ti stent to form a PDA coating, thereby preparing the 3D printing Ti-PDA stent; then PLGA microspheres carrying VEGF are prepared by a multiple emulsion-solvent evaporation method, and finally BMP-2 and the PLGA microspheres carrying VEGF are adsorbed and fixed on the surface of the stent by an adsorption method, and finally the 3D printing Ti-PDA-PLGA microsphere bone defect repair stent is formed. The tissue engineering scaffold for repairing bone defect has the advantages of reliable mechanical property, high bioactivity and safety, convenient implantation, small wound and low cost, and can be used for repairing and treating bone wound, bone tumor and bone defect after bone infection. |