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filingDate 2019-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2b36cd3e9331ed21133e7b09178e7b33
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publicationDate 2021-02-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-112293348-A
titleOfInvention A method for constructing a mouse model of lumbar disc herniation
abstract The invention discloses a method for constructing a mouse model of lumbar intervertebral disc herniation. Intervertebral disc nucleus pulposus tissue; 3) The spinal canal dural sac and nerve root were exposed through the posterior approach, and the degenerated intervertebral disc tissue was placed in the intervertebral foramen area to form nerve root compression to obtain a lumbar disc herniation mouse model; 4) Behavioral testing assesses the presentation and extent of radiating pain in the lower extremities. The invention utilizes the degenerated intervertebral disc tissue to compress the nerve root, which can induce severe and lasting radiating pain symptoms in the lower extremities, and better simulate the chronic course of clinical lumbar disc herniation; Reliable pain behavioral measurement methods and abundant transgenic strains will help to deeply explore the neurobiological mechanism of radiating pain in the lower extremity of lumbar disc herniation.
isCitedBy http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113274160-A
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Total number of triples: 26.