| abstract |
Therapeutic payloads comprising a p97 fragment conjugated to an active agent having Blood Brain Barrier (BBB) transport activity are disclosed, including variants thereof and combinations thereof, to facilitate the delivery of therapeutic or diagnostic agents across the BBB. The therapeutic payload has a dual function, which may allow for the treatment of diseases other than those present in the brain in a subject, such as solid tumors in vivo. Methods and pharmaceutical compositions for treating various diseases are also disclosed. |