http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112279785-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_de982ee9a57718adbba14825b83c7316 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02E60-10 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C259-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C209-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-307 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C209-54 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C259-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C209-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C209-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C211-37 |
| filingDate | 2020-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d3d85d057be1c74ca40883c408b55ef0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_785f759d67a84fecf68111d99c861c54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a81fcd98e701e684849c0bf89747aa76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_78b3bab3a6e6950731b24bbf407cdfb1 |
| publicationDate | 2021-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112279785-A |
| titleOfInvention | 3,3-Difluorocyclobutylamine hydrochloride intermediate and its synthesis method and 3,3-difluorocyclobutylamine hydrochloride synthesis method |
| abstract | The invention relates to a 3,3-difluorocyclobutylamine hydrochloride intermediate and its synthesis method and a 3,3-difluorocyclobutylamine hydrochloride synthesis method. First, 3-oxocyclobutane carboxylic acid Under acid catalysis, methyl ester compound is generated, after methyl ester compound is fluorinated to obtain fluoride, and then reacted with hydroxylamine to generate 3,3-difluorocyclobutylamine hydrochloride intermediate, 3,3-difluorocyclobutylamine salt Without purification and separation, the acid salt intermediate is rearranged in the same reaction system under the action of sulfonyl chloride and alkali to obtain 3,3-difluorocyclobutylamine, and finally 3,3-difluorocyclobutylamine is formed with hydrochloric acid. The salt yields 3,3-difluorocyclobutylamine hydrochloride. The method for synthesizing 3,3-difluorocyclobutylamine hydrochloride of the present invention does not need to use azide, the reaction conditions are mild, safe and environmentally friendly, the process route is simple, the production cycle is significantly shortened, the production capacity is advantageous, and the raw materials Simple and easy to obtain, low cost, suitable for industrialized large-scale production. |
| priorityDate | 2020-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 124.