http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112274491-A

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filingDate 2020-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6ec4df96d50c9f3233b10e2808273802
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publicationDate 2021-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-112274491-A
titleOfInvention Gatifloxacin effervescent tablet and preparation method thereof
abstract The invention relates to the field of medicine processing, and discloses a gatifloxacin effervescent tablet and a preparation method thereof. The gatifloxacin effervescent tablet comprises the following prescription and formula ratio: 100-200 mg of gatifloxacin, 30-50 mg of boric acid, 20-60 mg of sodium bicarbonate, 30-60 mg of dextrin, 50-100 mg of starch, 20-30 mg of sucrose and 801-3 mg of tween. The gatifloxacin effervescent tablet has the effective component of gatifloxacin, and is prepared with boric acid and sodium bicarbonate as effervescent disintegrant, Tween 80 as auxiliary component and stuffing comprising cane sugar, dextrin and starch as auxiliary component; the preparation method adopts acid-base wet granulation, and the prepared granules are uniformly mixed and tabletted. The gatifloxacin solid preparation on the market at present has tablets and capsules which are common dosage forms, and the invention adopts the modern pharmaceutical preparation technology to prepare the gatifloxacin solid preparation into effervescent tablets, thereby improving the dissolution rate and bioavailability of the gatifloxacin and playing the role of quick action and high efficiency.
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