| abstract |
The invention discloses a preparation method of amlodipine losartan potassium compound composition, which comprises mixing losartan potassium and hypromellose, adding microcrystalline cellulose and pregelatinized starch and mixing, and adding an appropriate amount of ethanol aqueous solution , granulation, drying to obtain losartan potassium dry granules, mixing amlodipine besylate and sodium carboxymethyl starch, adding microcrystalline cellulose and pregelatinized starch and mixing to obtain amlodipine mixed powder, The dry granules of sartan potassium, the mixed powder of amlodipine, silicon dioxide and magnesium stearate are mixed, compressed into tablets, and coated. |