| abstract |
The invention provides a preparation method of an α,α-difluoro-β-ketone sulfone compound, belonging to the technical field of chemistry. First, a composition for preparing the compound shown in formula I is provided, which is composed of the following components: compound 1, a fluoride initiator and an organic solvent; wherein, Ar 1 and Ar 2 are independently selected from substituted or unsubstituted Aryl, substituted or unsubstituted heteroatom aryl. Also provided is a method for preparing α,α-difluoro-β-ketone sulfone compounds from the composition. The present invention uses metal fluorides as initiators, and a series of compounds can be prepared under mild conditions. The preparation method has the advantages of simple synthetic route, good yield and high purity; has the advantages of excellent functional group adaptability and the like, can be used to prepare α,α-difluoro-β-ketone sulfone compounds with various functional groups, and is successfully applied to Late modification of natural products and drug molecules. In addition, the reaction scale of the present invention can be scaled up to the gram level, can be used for industrial scale-up production, and has good application prospects. |