abstract |
The present invention provides a compound of formula I or a pharmaceutically acceptable salt or composition thereof, methods of use and methods of preparing a complement factor D inhibitor comprising formula I or a pharmaceutically acceptable salt or composition thereof, wherein the A group is of R 12 or R 13 is an aryl group, a heteroaryl group or a heterocyclic group (R 32 ). The inhibitors described herein target factor D and inhibit or modulate the complement cascade at early and essential points in the alternative complement pathway, and reduce the ability of factor D to regulate the classical and lectin complement pathways. The inhibitors of Factor D described herein are able to reduce the overactivation of complement that is associated with certain autoimmune, inflammatory and neurodegenerative diseases as well as ischemia-reperfusion injury and cancer. |