http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112245428-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2236-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2236-333 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2236-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2236-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2236-39 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K36-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K36-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-435 |
| filingDate | 2020-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112245428-B |
| titleOfInvention | Application of compound capable of inhibiting interaction of coronavirus Spike protein and ACE2 |
| abstract | The invention discloses application of a compound capable of inhibiting interaction of coronavirus Spike protein and ACE 2. The structure is as follows, the application of the compound in preparing the medicine for treating and/or preventing SARS-CoV-2 novel coronavirus infection. Meanwhile, the compound can inhibit the interaction between the coronavirus Spike protein and the ACE2 protein, IC50<1 μ M, while being able to promote dissociation of the Spike-ACE2 complex. Can effectively inhibit the invasion of a novel coronavirus SARS-CoV-2 pseudovirus at a cellular level, IC50<2 μ M. The compound can be specifically combined in the RBD region, KD of the Spike protein<6 mu M, which shows that the compounds have very positive effect on preparing the medicaments for treating and/or preventing the coronavirus infection. |
| priorityDate | 2020-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 61.