http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112239432-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2531-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2531-37 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D285-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J31-2213 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D285-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J31-22 |
| filingDate | 2020-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112239432-B |
| titleOfInvention | Preparation method of chiral 3, 4-dihydrobenzothiadiazine compound |
| abstract | The invention relates to a preparation method of a chiral 3, 4-dihydrobenzothiadiazine compound, which comprises the following steps: adding a molecular sieve into the compounds shown in the formula (1) and the formula (2) under the action of a catalyst under the conditions of no water, no oxygen and protective atmosphere, and reacting in an organic solvent at-40 ℃ to obtain a chiral 3, 4-dihydrobenzothiadiazine compound shown in the formula (4); the catalyst comprises a chiral TADDOL type rare earth metal complex or a combined catalyst of a chiral TADDOL ligand and a lithium chloride-complexed rare earth metal amide; the reaction route is as follows: wherein R is 1 Selected from hydrogen, C 1 ‑C 4 Alkyl or halogen; r 2 Selected from hydrogen, C 1 ‑C 2 Alkyl or phenyl; r is 3 Is selected from C 1 ‑C 5 Alkyl radical, C 3 ‑C 6 Cycloalkyl, phenyl, benzyl, phenylpropyl, C 1 ‑C 4 Alkyl-substituted phenyl, C 1 ‑C 4 Alkoxy substituted phenyl, halophenyl, furyl, or thienyl. |
| priorityDate | 2020-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 26.