| abstract |
The present invention relates to an antibody or fragment thereof comprising at least one heterologous amino acid sequence incorporated into at least one CDR region of said antibody or fragment thereof, wherein said at least one heterologous amino acid sequence comprises an N-terminal linker sequence (Ntls), Atrial natriuretic peptide (ANP) and C-terminal linker sequence (Ctls). Optionally, at least a portion of the at least one CDR region is replaced by the at least one heterologous amino acid sequence incorporated therein. The present invention also relates to such antibodies or fragments thereof, compositions comprising such antibodies or fragments thereof, nucleic acids or mixtures of nucleic acids encoding such antibodies or fragments thereof, comprising such nucleic acids or such mixtures of nucleic acids for use in methods of treatment host cells, and methods involving the production of such antibodies or fragments thereof. |