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filingDate 2020-10-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e20cc8b57c62359f509ba7653f5d29f2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_459f537a3437900b4e388596e246d8a5
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publicationDate 2021-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-112226512-A
titleOfInvention Gene combination and method for malignant lymphoma liquid biopsy
abstract The invention discloses a gene combination and a method for malignant lymphoma liquid biopsy, wherein the lymphoma liquid biopsy technology is a non-invasive means for detecting circulating tumor DNA (ctDNA) by a blood sample. The invention provides a gene combination related to 93 malignant lymphomas and application thereof in detecting the malignant lymphomas by high-throughput sequencing. The method has the advantages of low ctDNA amount, strong clinical operability and capability of quickly detecting malignant lymphoma-related molecular abnormalities, and can meet the requirements by one-time blood collection; the invention has the advantages of convenient material taking, strong specificity and high sensitivity, and particularly, the invention can highlight the advantages when the material is difficult to be taken or can not be taken in lymph node pathology; the method carries out molecular subtype typing, genotyping prognosis layering, dynamic detection of tiny residual focus, drug resistance, relapse and the like on the lymphoma based on gene mutation, and is favorable for promoting the development of individual and accurate treatment of malignant lymphoma.
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