abstract |
The invention discloses a medical hydrogel, which is formed by in-situ cross-linking of aldehyde group-terminated star-shaped multi-arm polyethylene glycol and polyamino compounds, the aldehyde group and star-shaped multi-arm polyethylene glycol are separated by Ester linkage, the number of arms of the aldehyde-terminated star-shaped multi-arm polyethylene glycol is 2-8, and the molecular weight of a single arm is 1000-5000Da. The present invention selects the aldehyde group-terminated star-shaped multi-arm polyethylene glycol connected by ester bonds between the aldehyde group and the star-shaped multi-arm polyethylene glycol, and the star-shaped multi-arm polyethylene glycol has a specific number of arms and a molecular weight range, to obtain short-term degradable hydrogels. |