http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112225685-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-42 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-42 |
| filingDate | 2020-09-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112225685-B |
| titleOfInvention | 3-cyanoindole compound, preparation method and application thereof |
| abstract | The invention discloses a method for constructing 3-cyanoindole by a series reaction. The method comprises the following steps: the compound with the structure shown in the formula (1) and 4-isoxazole boronic acid pinacol ester are subjected to a suzuki reaction, isoxazole fragmentation is induced by alkali, and aldimine condensation is carried out, so that the 3-cyanoindole compound with the structure shown in the formula (2) is prepared. The invention selects a proper compound with the structure shown in the formula (1) as a substrate to realize the high-efficiency coupling of the compound with the structure shown in the formula (1), thereby preparing the 3-cyanoindole compound with the structure shown in the formula (2) at low cost. The 3-cyanoindole compound obtained by the invention can be used as a bioactive compound and a pharmaceutical intermediate. |
| priorityDate | 2020-09-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 83.