http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112220936-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-724 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-155 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6951 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G83-008 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-724 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-155 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-69 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G83-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 |
| filingDate | 2020-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112220936-B |
| titleOfInvention | Calixarene-GCA-cyclodextrin-CD co-assembly and its application in the preparation of drugs |
| abstract | The invention relates to a calixarene-GCA-cyclodextrin-CD co-assembly and its application in the preparation of medicines. The co-assembly is constructed by GCA and CD at a molar ratio of 1:1 through weak π-π interactions and hydrophobic interactions, which can achieve selective and strong bonding with β-amyloid through heteropolyvalent interactions, and can inhibit β-amyloid fibrilization, depolymerization of β-amyloid fibrils, reduction of β-amyloid oligomer content, and alleviation of the cytotoxicity of β-amyloid fibrils. The guanidine group on the surface of the co-assemblies facilitates the phagocytosis of β‑amyloid by microglia. Animal experiments have shown that the co-assembly can reduce the content of soluble and insoluble β-amyloid and β-amyloid oligomers in the brains of Alzheimer's mice, and can improve the Cognitive impairment. |
| priorityDate | 2020-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 54.