http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112216348-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2ad762b30604c204338aaebd44583bd7 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B25-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16H50-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16H70-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B50-30 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16B25-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16B50-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16H50-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16H70-40 |
| filingDate | 2020-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_82bc9340328a914ce19083ec9e4f0d42 |
| publicationDate | 2021-01-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112216348-A |
| titleOfInvention | A kind of osteosarcoma metastasis-related gene signature research and potential drug discovery method |
| abstract | The invention relates to the technical field of osteosarcoma metastasis-related genes, and discloses a method for the signature research and potential drug mining of osteosarcoma metastasis-related genes, comprising the following steps: S1, data downloading and preprocessing: performing the following steps on TARGET data of OS Preprocessing: 1) Remove samples with no clinical information or overall survival time <30 days; 2) Remove normal tissue sample data; 3) Remove genes whose expression level is 0 in more than half of the samples. This kind of osteosarcoma metastasis-related gene signature research and potential drug mining method, from the characteristics of gene expression level changes, immune-related genes are generally down-regulated in the metastatic group, it is speculated that the inhibition of the immune system may contribute to the metastasis of osteosarcoma, further indicating , the inhibition of the expression of some genes (including immune-related genes) may contribute to osteosarcoma metastasis. The prognostic analysis of MRS further identified a group of genes that have a significant relationship with prognosis, which provides a possible option for further mining the treatment of osteosarcoma metastasis . |
| priorityDate | 2020-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 48.