| abstract |
The invention discloses a preparation method of a chiral compound of formula (I), wherein: X 1 and X 2 are independently F or C1; E is -SO 2 R 2 , wherein R 2 is C 1 -C 6 alkane base, -C 6 H 4 CH 3 or -CF 3 ; its enantiomers and racemates, the compound can be used to synthesize tetrahydrofuranazole antifungal agents. The present invention also discloses new compounds of formula (II) or (III), wherein: X 1 and X 2 are independently F or C1; B represents -C(0)Q * or -CH 2 OR "; Q * represents Chiral auxiliary group; R "represents a hydroxyl protecting group; A represents C1, Br, I, triazolyl or imidazolyl. |