http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112209991-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0819 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4705 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-093 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 |
| filingDate | 2019-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112209991-B |
| titleOfInvention | Tripeptide Inhibitors of APC/Asef Interaction and Their Applications |
| abstract | The present invention provides an APC/Asef interaction tripeptide inhibitor, the tripeptide inhibitor comprising the amino acid sequence shown in formula (1) and a salt thereof: formula (1): P 1 -X1-X2-X3 ‑P 2 . The novel tripeptide provided by the invention plays an anti-tumor effect by inhibiting the interaction of APC/Asef protein in cancer cells. The N-terminus and C-terminus of the polypeptide are capped, which can form a strong hydrophobic interaction with the APC protein, and the amino acids with carboxyl groups contained in the polypeptide can form a strong electrostatic interaction with the basic amino acids in the APC protein. The configuration can fit with the APC protein pocket, so it can strongly inhibit the interaction of APC/Asef, thereby playing an anti-tumor therapeutic effect. The anti-tumor peptide of the invention has a broad spectrum, has inhibitory and killing effects on various cancer cells, has short peptide chain length, high anti-tumor activity, and is stable and not easy to be inactivated. |
| priorityDate | 2019-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 87.