| abstract |
The invention discloses 1-H benzimidazole series derivatives as shown in the figure, a preparation method and their application in the pharmaceutical field, especially the application in antitumor drugs. At the same time, it is determined that the derivatives A, B, C and E are the main related substances of the upcoming 1-H benzimidazole derivative NL-101, which can be used as the research process for the approval, analysis, identification and quality control of NL-101 Application of Chinese Standards. Analytical methods for NL-101 are also disclosed. |