| abstract |
The present invention provides compositions comprising immunotherapeutic agents, such as chimeric antigen receptor T cells (CAR-T cells), and particularly those targeting tumor antigens cleaved by gamma secretase, and a difluoroalkyl group ‑1,4‑Benzodiazepine Ketone compounds, including compounds of formula (I) or prodrugs thereof; and methods of use thereof in the treatment of diseases and conditions such as cancer. |