http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112194730-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-08 |
| filingDate | 2020-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112194730-B |
| titleOfInvention | Polypeptide TI-16 and application thereof |
| abstract | The invention belongs to the technical field of biological medicines, and particularly relates to a polypeptide TI-16 and application thereof. The polypeptide TI-16 has the amino acid sequence of SEQ ID No1, the N-terminal of the polypeptide TI-16 is connected with 11 amino acid leading cell penetrating peptides, the amino acid sequence of SEQ ID No.2 can carry the following 16 amino acids to penetrate cell membranes, and the following 16 amino acids SEQ ID No.3 are main bodies playing roles. The application of the polypeptide in preparing a medicament for treating Alzheimer disease. The polypeptide can react with Abeta in vitro 1‑42 Binding and having a certain calcium concentration dependence; the polypeptide provided by the invention can penetrate cell membranes to enter nerve cells to inhibit A beta 25‑35 The resulting nerve cell damage; the polypeptide provided by the invention does not influence the nerve function, has a certain repairing effect on AD caused by Abeta, and lays a foundation for the treatment of AD. |
| priorityDate | 2020-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 170.