http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112190561-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2095 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2054 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2059 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2009 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-43 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-424 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-424 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-43 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-36 |
| filingDate | 2020-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-02-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-02-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112190561-B |
| titleOfInvention | Preparation method of amoxicillin and clavulanate potassium tablets |
| abstract | The invention discloses a preparation method of an amoxicillin and clavulanate potassium tablet, which comprises the following steps: mixing and drying amoxicillin heavy powder, microcrystalline cellulose and colloidal silicon dioxide until the water activity of the mixed powder is less than 0.05aW to obtain mixed powder I; adding a mixed raw material of potassium clavulanate and microcrystalline cellulose, carboxymethyl starch sodium, colloidal silicon dioxide and microcrystalline cellulose into the mixed powder I, and mixing to obtain mixed powder II; adding magnesium stearate into the mixed powder II, and mixing to obtain mixed powder II; directly tabletting the mixed powder III to obtain amoxicillin and clavulanate potassium tablets; taking the compressed amoxicillin potassium clavulanate tablets as tablet core coatings to obtain finished amoxicillin potassium clavulanate tablets; wherein the mass ratio of amoxicillin to clavulanic acid is 7:1, and the coating solvent is a mixed solution of isopropanol and dichloromethane. The invention obtains the amoxicillin and clavulanate potassium tablet product with good stability and dissolution rate by improving the combination relationship of the components and the preparation process. |
| priorityDate | 2020-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 44.