| abstract |
The invention belongs to the technical field of pharmaceutical preparations, and relates to a type of penetration enhancer for nasal administration and application thereof. The present invention relates to a type of penetration enhancer for promoting nasal absorption, specifically, the penetration enhancer is a low-temperature molten salt for promoting nasal absorption; it is formed by the reaction of an organic acid with at least one organic base and/or its salt. Ionic liquids or deep eutectic solvents. The penetration enhancer can dissolve active ingredients including insoluble drugs and biological macromolecular drugs, for example, it can significantly promote the nasal absorption of insulin to achieve an ideal hypoglycemic effect. The penetration enhancer of the present invention can be used alone or in combination with other carriers to promote the transport of drug molecules across the nasal mucosa, and has no obvious damage to the nasal mucosa. |