| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_67aa3bc75203266389dcde6a7cb83250 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B2503-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B2503-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G06T2207-10104 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B6-037
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16H30-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B6-481
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G06T7-33 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16H30-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61B6-03
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61B6-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G06T7-33 |
| filingDate |
2020-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3fc8a941e0b675c082f6f3cb63a9ff0a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_625b719b864823807047cb15d7e78cbd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dd6861a63c332235d1ee7ab25ed8dbca
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b4c855b41058fda5c1b728caf0b17b51
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9716efbb280ac3e613abdf09f05b2ed8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_16e26a9a08ef55a5ca2477aec96c2f90
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7afc73f4f25b8c4519bc9f0cd1f29056 |
| publicationDate |
2021-01-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-112185518-A |
| titleOfInvention |
Developing method of TSPO translocator PET probe in neuroinflammation |
| abstract |
The invention relates to a method for developing a TSPO translocator PET probe in neuroinflammation, belonging to the technical field of medical imaging. The method comprises the steps of establishing a cerebral ischemia rat model, and carrying out PET imaging treatment by using a small animal PET scanner; the binding specificity of 18F-VUIIS1009A and 18F-VUIIS1009B were evaluated separately; performing PET image co-registration and analysis, and performing imaging analysis by using an arterial plasma input function AIF (automated air imaging) to generate a Logan graph and a parameter image of a total distribution volume VT of each radioactive tracer; generating a parametric image for a binding capacity constant BPND by using a reference Logan model with a healthy brain as a reference region; and statistical analysis is performed. The invention can more accurately reflect the expression condition of TSPO in the nervous system diseases, thereby more accurately evaluating the progression degree of neuroinflammation in various nervous system diseases. |
| priorityDate |
2020-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |